5d9g: Difference between revisions
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==Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide== | |||
<StructureSection load='5d9g' size='340' side='right' caption='[[5d9g]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5d9g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D9G FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[ | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9g OCA], [http://pdbe.org/5d9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d9g RCSB], [http://www.ebi.ac.uk/pdbsum/5d9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9g ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TIPRL_HUMAN TIPRL_HUMAN]] May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.<ref>PMID:17384681</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aparicio, R]] | [[Category: Aparicio, R]] | ||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
[[Category: Pereira, H | [[Category: Pereira, H M]] | ||
[[Category: Sandy, J]] | |||
[[Category: Scorsato, V]] | [[Category: Scorsato, V]] | ||
[[Category: | [[Category: Smetana, J H.C]] | ||
[[Category: Protein binding]] | |||
[[Category: Protein binding tip41-like family pp2a]] | |||
Revision as of 16:21, 10 August 2016
Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide
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