5dil: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5dil is ~~ON HOLD until Paper Publication~~

==Crystal structure of the effector domain of the NS1 protein from influenza virus B==

~~Authors~~: ~~Guan~~, R., ~~Hamilton~~, K., ~~Ma, L~~., ~~Montelione, G~~.T.

== Structural highlights ==

<table><tr><td colspan='2'>[[5dil]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIL FirstGlance].

~~Description~~: ~~Crystal structure of~~ the ~~effector domain of~~ the ~~NS1 protein from influenza virus B~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>

[~~[Category~~: ~~Unreleased Structures]~~]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

[[Category: ~~Montelione~~, ~~G.T~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dil OCA], [http://pdbe.org/5dil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dil RCSB], [http://www.ebi.ac.uk/pdbsum/5dil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dil ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/X2C382_9INFB X2C382_9INFB]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[PIRNR:PIRNR003938]

__TOC__

</StructureSection>

[[Category: Guan, R]]

[[Category: Hamilton, K]]

[[Category: Ma, L]]

[[Category: ~~Guan~~, R]]

[[Category: Montelione, G T]]

[[Category: Effector domain]]

[[Category: Rna binding]]

[[Category: Rna-binding protein]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5dil is ON HOLD  until Paper Publication
+==Crystal structure of the effector domain of the NS1 protein from influenza virus B==
+<StructureSection load='5dil' size='340' side='right' caption='[[5dil]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
-Authors: Guan, R., Hamilton, K., Ma, L., Montelione, G.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5dil]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIL FirstGlance]. <br>
-Description: Crystal structure of the effector domain of the NS1 protein from influenza virus B
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-[[Category: Montelione, G.T]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dil OCA], [http://pdbe.org/5dil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dil RCSB], [http://www.ebi.ac.uk/pdbsum/5dil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dil ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/X2C382_9INFB X2C382_9INFB]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[PIRNR:PIRNR003938]
+__TOC__
+</StructureSection>
+[[Category: Guan, R]]
 [[Category: Hamilton, K]]
 [[Category: Ma, L]]
-[[Category: Guan, R]]
+[[Category: Montelione, G T]]
+[[Category: Effector domain]]
+[[Category: Rna binding]]
+[[Category: Rna-binding protein]]
+[[Category: Viral protein]]