5fjv: Difference between revisions
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==Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly== | |||
<StructureSection load='5fjv' size='340' side='right' caption='[[5fjv]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fjv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FJV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPJ:EPIBATIDINE'>EPJ</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fjv OCA], [http://pdbe.org/5fjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fjv RCSB], [http://www.ebi.ac.uk/pdbsum/5fjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fjv ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] Autosomal dominant nocturnal frontal lobe epilepsy. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chroni-Tzartou, D]] | [[Category: Chroni-Tzartou, D]] | ||
[[Category: Giastas, P]] | [[Category: Giastas, P]] | ||
[[Category: Kouvatsos, N]] | [[Category: Kouvatsos, N]] | ||
[[Category: Tzartos, S | [[Category: Tzartos, S J]] | ||
[[Category: Acetylcholine-binding protein]] | |||
[[Category: Agonist]] | |||
[[Category: Alpha2]] | |||
[[Category: Epibatidine]] | |||
[[Category: Extracellular domain]] | |||
[[Category: Nachr]] | |||
[[Category: Nicotinic acetylcholine receptor]] | |||
Revision as of 16:24, 10 August 2016
Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
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