5i2c: Difference between revisions
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==Arginine-bound CASTOR1 from Homo sapiens== | |||
<StructureSection load='5i2c' size='340' side='right' caption='[[5i2c]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5i2c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I2C FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2c OCA], [http://pdbe.org/5i2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2c RCSB], [http://www.ebi.ac.uk/pdbsum/5i2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2c ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Knockenhauer, K E]] | |||
[[Category: Saxton, R A]] | |||
[[Category: Schwartz, T U]] | |||
[[Category: Act]] | |||
[[Category: Arginine]] | |||
[[Category: Mtor]] | |||
[[Category: Signaling]] | |||
[[Category: Signaling protein]] | |||
Revision as of 16:26, 10 August 2016
Arginine-bound CASTOR1 from Homo sapiens
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