5l7k: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
The | ==The crystal structure of myristoylated NPHP3 peptide in complex with UNC119a== | ||
<StructureSection load='5l7k' size='340' side='right' caption='[[5l7k]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l7k]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L7K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7k OCA], [http://pdbe.org/5l7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7k RCSB], [http://www.ebi.ac.uk/pdbsum/5l7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7k ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/U119A_HUMAN U119A_HUMAN]] Idiopathic CD4 lymphocytopenia;Cone rod dystrophy. Defects in UNC119 may be a cause of cone-rod dystrophy. A mutation was found in a 57-year-old woman with late-onset cone-rod dystrophy: from 40 year old, the patient suffered from poor night vision, defective color vision and light-sensitivity. At 57 year old, she displayed reduced visual acuity, myopa, macular atrophy and pericentral ring scotomas. The disease was caused by a heterozygous mutation causing premature termination and truncated UNC119 protein with dominant-negative effect. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/U119A_HUMAN U119A_HUMAN]] Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.<ref>PMID:22085962</ref> <ref>PMID:21642972</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Fansa, E K]] | |||
[[Category: Jaiswal, M]] | |||
[[Category: Wittinghofer, A]] | [[Category: Wittinghofer, A]] | ||
[[Category: | [[Category: Beta-sandwish]] | ||
[[Category: Lipid binding protein]] | |||
[[Category: Myristoylation]] | |||
[[Category: Protein transport]] | |||
Revision as of 16:31, 10 August 2016
The crystal structure of myristoylated NPHP3 peptide in complex with UNC119a
| ||||||||||||
