1nfk: Difference between revisions
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|PDB= 1nfk |SIZE=350|CAPTION= <scene name='initialview01'>1nfk</scene>, resolution 2.300Å | |PDB= 1nfk |SIZE=350|CAPTION= <scene name='initialview01'>1nfk</scene>, resolution 2.300Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nfk OCA], [http://www.ebi.ac.uk/pdbsum/1nfk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nfk RCSB]</span> | |||
}} | }} | ||
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[[Category: nf-kb p50]] | [[Category: nf-kb p50]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:29:40 2008'' | ||
Revision as of 19:29, 30 March 2008
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| 1nfk, resolution 2.300Å | |||||||||||||
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| Ligands: | DA, DC, DG, DT | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER
Overview
The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region folds into two distinct domains, similar to those in the immunoglobulin superfamily. The p50 dimer envelopes an undistorted B-DNA helix, making specific contacts along the 10-base-pair kappa B recognition site mainly through loops connecting secondary structure elements in both domains. The carboxy-terminal domains form a dimerization interface between beta-sheets using residues that are strongly conserved in the Rel family.
About this Structure
1NFK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of NF-kappa B p50 homodimer bound to a kappa B site., Ghosh G, van Duyne G, Ghosh S, Sigler PB, Nature. 1995 Jan 26;373(6512):303-10. PMID:7530332
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