3u7m: Difference between revisions

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==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==

== Structural highlights ==

<table><tr><td colspan='2'>[[3u7m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7M OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7M FirstGlance].

<table><tr><td colspan='2'>[[3u7m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7M OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7M FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=FHF:N-((2R,4S)-2-BUTYL-4-(3-(2-FLUOROPHENYL)UREIDO)-5-METHYL-3-OXOHEXYL)-N-HYDROXYFORMAMIDE'>FHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3u7k|3u7k]], [[3u7l|3u7l]], [[3u7n|3u7n]]</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">sacol1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1280 Staphylococcus aureus~~])</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">sacol1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7m RCSB], [http://www.ebi.ac.uk/pdbsum/3u7m PDBsum]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7m OCA], [http://pdbe.org/3u7m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7m RCSB], [http://www.ebi.ac.uk/pdbsum/3u7m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7m ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]

__TOC__

</StructureSection>

[[Category: Peptide deformylase]]

[[Category: ~~Staphylococcus aureus~~]]

[[Category: Staac]]

[[Category: Kim, K K]]

[[Category: Lee, B J]]

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 ==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==
 <StructureSection load='3u7m' size='340' side='right' caption='[[3u7m]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3u7m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7M FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3u7m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7M FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FHF:N-((2R,4S)-2-BUTYL-4-(3-(2-FLUOROPHENYL)UREIDO)-5-METHYL-3-OXOHEXYL)-N-HYDROXYFORMAMIDE'>FHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u7k|3u7k]], [[3u7l|3u7l]], [[3u7n|3u7n]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sacol1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sacol1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7m RCSB], [http://www.ebi.ac.uk/pdbsum/3u7m PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7m OCA], [http://pdbe.org/3u7m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7m RCSB], [http://www.ebi.ac.uk/pdbsum/3u7m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7m ProSAT]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
 __TOC__
 </StructureSection>
 [[Category: Peptide deformylase]]
-[[Category: Staphylococcus aureus]]
+[[Category: Staac]]
 [[Category: Kim, K K]]
 [[Category: Lee, B J]]