4cxx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of human FTO in complex with acylhydrazine inhibitor 16== | ==Crystal structure of human FTO in complex with acylhydrazine inhibitor 16== | ||
<StructureSection load='4cxx' size='340' side='right' caption='[[4cxx]], [[Resolution|resolution]] 2.76Å' scene=''> | <StructureSection load='4cxx' size='340' side='right' caption='[[4cxx]], [[Resolution|resolution]] 2.76Å' scene=''> | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=640:(2E)-4-{N-[4-(4-TERT-BUTYL-BENZYL)-PYRIDINE-3-CARBONYL]-HYDRAZINO}-4-OXO-BUT-2-ENOIC+ACID'>640</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=640:(2E)-4-{N-[4-(4-TERT-BUTYL-BENZYL)-PYRIDINE-3-CARBONYL]-HYDRAZINO}-4-OXO-BUT-2-ENOIC+ACID'>640</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cxw|4cxw]], [[4cxy|4cxy]], [[4cxz|4cxz]], [[4cy0|4cy0]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cxw|4cxw]], [[4cxy|4cxy]], [[4cxz|4cxz]], [[4cy0|4cy0]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxx RCSB], [http://www.ebi.ac.uk/pdbsum/4cxx PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxx OCA], [http://pdbe.org/4cxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cxx RCSB], [http://www.ebi.ac.uk/pdbsum/4cxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| Line 11: | Line 12: | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref> | [[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref> | ||
==See Also== | |||
*[[Dioxygenase|Dioxygenase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
