4tw9: Difference between revisions

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==Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation==
==Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation==
<StructureSection load='4tw9' size='340' side='right' caption='[[4tw9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4tw9' size='340' side='right' caption='[[4tw9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<table><tr><td colspan='2'>[[4tw9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4tw9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=386:N-(2,2-DIFLUORO-5H-[1,3]DIOXOLO[4,5-F]BENZIMIDAZOL-6-YL)-2-{[2-(TRIFLUOROMETHOXY)BENZOYL]AMINO}-1,3-THIAZOLE-4-CARBOXAMIDE'>386</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HSJ:OCTYL+BETA-L-TALOPYRANOSIDE'>HSJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=386:N-(2,2-DIFLUORO-5H-[1,3]DIOXOLO[4,5-F]BENZIMIDAZOL-6-YL)-2-{[2-(TRIFLUOROMETHOXY)BENZOYL]AMINO}-1,3-THIAZOLE-4-CARBOXAMIDE'>386</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HSJ:OCTYL+BETA-L-TALOPYRANOSIDE'>HSJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw9 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw9 OCA], [http://pdbe.org/4tw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tw9 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4tw9" style="background-color:#fffaf0;"></div>
==See Also==
*[[Casein kinase|Casein kinase]]
== References ==
== References ==
<references/>
<references/>