4cxw: Difference between revisions
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==Crystal structure of human FTO in complex with subfamily-selective inhibitor 12== | ==Crystal structure of human FTO in complex with subfamily-selective inhibitor 12== | ||
<StructureSection load='4cxw' size='340' side='right' caption='[[4cxw]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='4cxw' size='340' side='right' caption='[[4cxw]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MK:(2E)-4-[N-(4-BENZYL-PYRIDINE-3-CARBONYL)-HYDRAZINO]-4-OXO-BUT-2-ENOIC+ACID'>6MK</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MK:(2E)-4-[N-(4-BENZYL-PYRIDINE-3-CARBONYL)-HYDRAZINO]-4-OXO-BUT-2-ENOIC+ACID'>6MK</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cxx|4cxx]], [[4cxy|4cxy]], [[4cxz|4cxz]], [[4cy0|4cy0]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cxx|4cxx]], [[4cxy|4cxy]], [[4cxz|4cxz]], [[4cy0|4cy0]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxw RCSB], [http://www.ebi.ac.uk/pdbsum/4cxw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxw OCA], [http://pdbe.org/4cxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cxw RCSB], [http://www.ebi.ac.uk/pdbsum/4cxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref> | [[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref> | ||
==See Also== | |||
*[[Dioxygenase|Dioxygenase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
