Plasminogen

spinqualitylabelsall models Human glycosylated plasminogen complex with acetate, bicarbonate, K+ (purple) and Cl- (green) ions (PDB entry 4dur) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. Microplasmin induces posterior vitreous detachment from the retina (PVD). Disease PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces. Structural highlights PLN contains 7 domains which are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds, e.g. Kringle 4. The kringle domain is important in protein-protein interaction with blood coagulation factors.. K ion coordination site. Water molecules shown as red spheres. Cl ion coordination site I. Cl ion coordination site II. Cl ion coordination site III. Cl ion coordination site IV.

3D Structures of plasminogen

Updated on 15-August-2016

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• Plasminogen
  • 4dur, 4duu, 4a5t – hPLG 2 - human
• Plasminogen kringle 1
  • 1pkr - hPLG kringle 1
    
  • 1cea - hPLG kringle 1 + e-aminocaprioic acid
    
  • 1hpj, 1hpk - hPLG kringle 1 + 6-aminohexanoic acid - NMR
    
  • 1ceb - hPLG kringle 1 + AMCHA
    
  • 4cik - hPLG kringle 1 + inhibitor
    
• Plasminogen kringle 2
  • 1b2i - hPLG kringle 2 (mutant) – NMR
    
  • 1i5k - hPLG kringle 2 (mutant) + M2 protein peptide
    
  • 2kj4 – hPLG kringle 2 + M2 protein peptide – NMR
    
• Plasminogen kringle 3
  • 2l0s - hPLG kringle 3 – NMR
    
• Plasminogen kringle 4
  • 1pk4, 1pmk, 1pml, 1krn – hPLG kringle 4
    
  • 2pk4 - hPLG kringle 4 + e-aminocaprioic acid
• Plasminogen kringle 5
  • 5hpg - hPLG kringle 5
    
  • 2knf - hPLG kringle 5 – NMR
    
• Plasminogen catalytic domain
  • 1qrz, 1ddj, 1rjx – hPLG catalytic domain (mutant)
    
  • 1l4d, 1l4z - hPLG catalytic domain (mutant) + streptokinase α domain
• Plasmin
  • 1bml – hPLN catalytic domain + streptokinase
    
  • 1bui – hPLN light chain + staphylokinase
• Microplasmin
  • 3uir – hPLN + textilinin-1
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman