User:John Karanicolas: Difference between revisions

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Dr. John Karanicolas is currently an associate professor in the Center for Computational Biology and the Department of Molecular Biosciences at the University of Kansas.
Dr. John Karanicolas is currently an associate professor at the Fox Chase Cancer Center.


Dr. Karanicolas was granted a PhD from The Scripps Research Institute in 2003. He carried out his graduate studies in the laboratory of Professor Charles L. Brooks III, where he studied protein folding through analysis of molecular dynamics simulations. He has since completed a postdoctoral fellowship in the laboratory of Professor David Baker, at the University of Washington. Here, Dr. Karanicolas carried out theoretical and/or experimental aspects of several design projects, including altering the allosteric mechanism of integrin signal transduction and designing a peptide to inhibit tau fibril formation. His postdoctoral accomplishments culminated in his design of a de novo protein-protein interface from two proteins with no natural affinity for each other.
His primary goal is to develop structure-based approaches for modulating protein function using small-molecules. His lab explores two parallel paths towards this overarching goal: the first is re-engineering proteins so that a small-molecule can be used to “turn on” function, and the second is identifying small-molecules that naturally complement and occlude a protein surface to “turn off” function. They apply these tools to understand how specific protein interactions are responsible for normal and aberrant signal transduction in cells.
 
Dr. Karanicolas stresses his enthusiasm to apply protein design methodology as an effective means to deconstruct the complexity in a system of particular biomedical interest, cytokine signaling. Carefully designed molecules will reduce cytokine signaling to a series of single well-defined responses, allowing clear delineation of these complex pathways and leading to a new class of therapeutics.

Latest revision as of 18:16, 20 August 2016

Dr. John Karanicolas is currently an associate professor at the Fox Chase Cancer Center.

His primary goal is to develop structure-based approaches for modulating protein function using small-molecules. His lab explores two parallel paths towards this overarching goal: the first is re-engineering proteins so that a small-molecule can be used to “turn on” function, and the second is identifying small-molecules that naturally complement and occlude a protein surface to “turn off” function. They apply these tools to understand how specific protein interactions are responsible for normal and aberrant signal transduction in cells.

Proteopedia Page Contributors and Editors (what is this?)

Eran Hodis, John Karanicolas

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