Saposin: Difference between revisions
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{{STRUCTURE_2dob| PDB=2dob | SIZE=400| SCENE= |right|CAPTION=Human saposin A complex with Ca+2 ion, [[2dob]] }} | {{STRUCTURE_2dob| PDB=2dob | SIZE=400| SCENE= |right|CAPTION=Human saposin A complex with Ca+2 ion, [[2dob]] }} | ||
== Function == | == Function == | ||
'''Saposin''' (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains and 2 SapA domains which are cleaved off<ref>PMID:2001789</ref>. | '''Saposin''' (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains (cleaved to saposin A,B,C and D) and 2 SapA domains which are cleaved off<ref>PMID:2001789</ref>. | ||
*'''Saposin A and C''' stimulate hydrolysis of methylumbelliferyl β-galactoside by β-glucosylceramidase and of galactocerebrocide by β-galactosylceramidase<ref>PMID:2717620</ref>. For more details see [[Molecular Playground/Saposin C]].<br /> | *'''Saposin A and C''' stimulate hydrolysis of methylumbelliferyl β-galactoside by β-glucosylceramidase and of galactocerebrocide by β-galactosylceramidase<ref>PMID:2717620</ref>. For more details see [[Molecular Playground/Saposin C]].<br /> | ||
