Squalene synthase

spinqualitylabelsall models Structure of human SQS complex with FPP analog (PDB code 3wef). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Squalene synthase (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol. Relevance SQS inhibitors are tested for antihyperlipidemic and antiatherosclerotic agents.

3D structures of squalene synthase

Updated on 31-August-2016

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• Squalene synthase
  • 3vj8, 3vjb – hSQS – human
    
  • 1ezf – hSQS (mutant)
    
  • 4hd1 – SQS – Alicyclobacillus acidocaldarius
    
• Squalene synthase complexes
  • 3lee – hSQS + Mg + bisphosphonate inhibitor
    
  • 3asx, 3q2z, 3q30 – hSQS + Mg + PO4 + inhibitor
    
  • 3vj9, 3vja – hSQS + Ni
    
  • 3vjc – hSQS + Mg + PO4 + zaragozic acid
    
  • 3v66 – hSQS + PO4 + inhibitor
    
  • 3wef – hSQS + FPP analog
    
  • 3weg – hSQS + Mg + FPP analog
    
  • 3weh – hSQS + Mg + presqualene pyrophosphate
    
  • 3wei – hSQS (mutant) + Mn + presqualene pyrophosphate
    
  • 3wej, 3wek – hSQS (mutant) + Mg + presqualene pyrophosphate
    
  • 3wc9 – hSQS (mutant) + farnesyl thiopyrophosphate
    
  • 3wcd – hSQS (mutant) + phenoxy thiocyanate derivative
    
  • 3wcf, 3wch, 3wci, 3wcl – hSQS (mutant) + imidazole phosphonate derivative
    
  • 3wcj – hSQS (mutant) + pyrrolidine derivative
    
  • 3wcm – hSQS (mutant) + pyridine derivative
    
  • 3wsa – hSQS (mutant) + tuberculosis drug
    

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