5k8q: Difference between revisions
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==Crystal Structure of Calcium-loaded Calmodulin in complex with STRA6 CaMBP2-site peptide.== | |||
<StructureSection load='5k8q' size='340' side='right' caption='[[5k8q]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5k8q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K8Q FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k8q OCA], [http://pdbe.org/5k8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k8q RCSB], [http://www.ebi.ac.uk/pdbsum/5k8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k8q ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Vitamin A homeostasis is critical to normal cellular function. Retinol-binding protein (RBP) is the sole specific carrier in the bloodstream for hydrophobic retinol, the main form in which vitamin A is transported. The integral membrane receptor STRA6 mediates cellular uptake of vitamin A by recognizing RBP-retinol to trigger release and internalization of retinol. We present the structure of zebrafish STRA6 determined to 3.9-angstrom resolution by single-particle cryo-electron microscopy. STRA6 has one intramembrane and nine transmembrane helices in an intricate dimeric assembly. Unexpectedly, calmodulin is bound tightly to STRA6 in a noncanonical arrangement. Residues involved with RBP binding map to an archlike structure that covers a deep lipophilic cleft. This cleft is open to the membrane, suggesting a possible mode for internalization of retinol through direct diffusion into the lipid bilayer. | |||
Structure of the STRA6 receptor for retinol uptake.,Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia F Science. 2016 Aug 26;353(6302). pii: aad8266. doi: 10.1126/science.aad8266. PMID:27563101<ref>PMID:27563101</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: Cavalier, M | <div class="pdbe-citations 5k8q" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
[[Category: Clarke, O | __TOC__ | ||
</StructureSection> | |||
[[Category: Cavalier, M C]] | |||
[[Category: Clarke, O B]] | |||
[[Category: Godoy-Ruiz, R]] | [[Category: Godoy-Ruiz, R]] | ||
[[Category: Mancia, F]] | [[Category: Mancia, F]] | ||
[[Category: Stowe, S D]] | |||
[[Category: Weber, D J]] | |||
[[Category: Calmodulin]] | |||
[[Category: Metal binding protein]] | |||
[[Category: Peptide complex]] | |||
[[Category: Stra6]] | |||
[[Category: Unique fold]] | |||
Revision as of 04:29, 9 September 2016
Crystal Structure of Calcium-loaded Calmodulin in complex with STRA6 CaMBP2-site peptide.
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