5ffl: Difference between revisions
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==Crystal structure of mouse CD300lf at 1.6 Angstroms resolution.== | |||
<StructureSection load='5ffl' size='340' side='right' caption='[[5ffl]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ffl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FFL FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ffl OCA], [http://pdbe.org/5ffl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ffl RCSB], [http://www.ebi.ac.uk/pdbsum/5ffl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ffl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLM1_MOUSE CLM1_MOUSE]] Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.<ref>PMID:14662855</ref> <ref>PMID:17438331</ref> <ref>PMID:18097021</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Noroviruses (NoVs) are a leading cause of gastroenteritis globally, yet the host factors required for NoV infection are poorly understood. We identified host molecules that are essential for murine NoV (MNoV)-induced cell death, including CD300lf as a proteinaceous receptor. We found that CD300lf is essential for MNoV binding and replication in cell lines and primary cells. Additionally, Cd300lf(-/-) mice are resistant to MNoV infection. Expression of CD300lf in human cells breaks the species barrier that would otherwise restrict MNoV replication. The crystal structure of the CD300lf ectodomain reveals a potential ligand-binding cleft composed of residues that are critical for MNoV infection. Therefore, the presence of a proteinaceous receptor is the primary determinant of MNoV species tropism, whereas other components of cellular machinery required for NoV replication are conserved between humans and mice. | |||
Discovery of a proteinaceous cellular receptor for a norovirus.,Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug, 18. PMID:27540007<ref>PMID:27540007</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5ffl" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Fremont, D H]] | |||
[[Category: Nelson, C A]] | |||
[[Category: Cd300 molecule-like family member f]] | |||
[[Category: Cd300f]] | |||
[[Category: Cd300lf]] | |||
[[Category: Cell surface receptor]] | |||
[[Category: Clm-1]] | |||
[[Category: Clm1]] | |||
[[Category: Ig superfamily]] | |||
[[Category: Igsf13]] | |||
[[Category: Immune system]] | |||
[[Category: Immunoglobulin superfamily member]] | |||
[[Category: Inhibitory receptor]] | |||
[[Category: Irem-1]] | |||
[[Category: Irem1]] | |||
[[Category: Lmir3]] | |||
[[Category: Nkir]] | |||
