5a5i: Difference between revisions
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==Cytochrome 2C9 P450 inhibitor complex== | |||
<StructureSection load='5a5i' size='340' side='right' caption='[[5a5i]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A5I FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=XI1:N-[4-(3-CHLORANYL-4-CYANO-PHENOXY)CYCLOHEXYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>XI1</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a5j|5a5j]]</td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5i OCA], [http://pdbe.org/5a5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a5i RCSB], [http://www.ebi.ac.uk/pdbsum/5a5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5i ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Groot, M J.de]] | |||
[[Category: Phillips, C]] | [[Category: Phillips, C]] | ||
[[Category: | [[Category: Skerratt, S E]] | ||
[[Category: Oxidoreductase]] | |||
Revision as of 06:48, 10 September 2016
Cytochrome 2C9 P450 inhibitor complex
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