5ko9: Difference between revisions

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'''Unreleased structure'''


The entry 5ko9 is ON HOLD  until Aug 24 2017
==Crystal Structure of the SRAP Domain of Human HMCES Protein==
 
<StructureSection load='5ko9' size='340' side='right' caption='[[5ko9]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
Authors: Halabelian, L., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ko9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KO9 FirstGlance]. <br>
Description: Crystal Structure of the SRAP Domain of Human HMCES Protein (CASP target)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ko9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ko9 OCA], [http://pdbe.org/5ko9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ko9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ko9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ko9 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Edwards, A M]]
[[Category: Halabelian, L]]
[[Category: Li, Y]]
[[Category: Li, Y]]
[[Category: Halabelian, L]]
[[Category: Structural genomic]]
[[Category: Bountra, C]]
[[Category: Dna binding protein]]
[[Category: Arrowsmith, C.H]]
[[Category: Dna-binding]]
[[Category: Edwards, A.M]]
[[Category: Sgc]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Srap domain]]

Revision as of 06:54, 10 September 2016

Crystal Structure of the SRAP Domain of Human HMCES Protein

5ko9, resolution 1.50Å

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