5ei3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ei3 is ~~ON HOLD until Paper Publication~~

==Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.==

~~Authors~~: ~~Nowicki~~, M.W., ~~Walkinshaw~~, M.D., ~~Fischer~~, P.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ei3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EI3 FirstGlance]. <br>

~~Description~~: Co-~~crystal structure~~ of ~~eIF4E with nucleotide mimetic inhibitor~~.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O8:~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-AZANYL-6-OXIDANYLIDENE-7-(PHENYLMETHYL)-1~{H}-PURIN-7-IUM-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>5O8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ei3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ei3 OCA], [http://pdbe.org/5ei3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ei3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ei3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ei3 ProSAT]</span></td></tr>

[[Category: Nowicki, M.W]]

</table>

[[Category: ~~Fischer~~, P.M]]

== Function ==

[[Category: ~~Walkinshaw, M.D~~]]

[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fischer, P M]]

[[Category: Nowicki, M W]]

[[Category: Walkinshaw, M D]]

[[Category: Complex]]

[[Category: Eif4e]]

[[Category: Inhibitor]]

[[Category: Translation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ei3 is ON HOLD  until Paper Publication
+==Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.==
+<StructureSection load='5ei3' size='340' side='right' caption='[[5ei3]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
-Authors: Nowicki, M.W., Walkinshaw, M.D., Fischer, P.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ei3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EI3 FirstGlance]. <br>
-Description: Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O8:~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-AZANYL-6-OXIDANYLIDENE-7-(PHENYLMETHYL)-1~{H}-PURIN-7-IUM-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>5O8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ei3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ei3 OCA], [http://pdbe.org/5ei3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ei3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ei3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ei3 ProSAT]</span></td></tr>
-[[Category: Nowicki, M.W]]
+</table>
-[[Category: Fischer, P.M]]
+== Function ==
-[[Category: Walkinshaw, M.D]]
+[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fischer, P M]]
+[[Category: Nowicki, M W]]
+[[Category: Walkinshaw, M D]]
+[[Category: Complex]]
+[[Category: Eif4e]]
+[[Category: Inhibitor]]
+[[Category: Translation]]