5eir: Difference between revisions
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==Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.== | |||
<StructureSection load='5eir' size='340' side='right' caption='[[5eir]], [[Resolution|resolution]] 2.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5eir]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EIR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O8:~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-AZANYL-6-OXIDANYLIDENE-7-(PHENYLMETHYL)-1~{H}-PURIN-7-IUM-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>5O8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v8w|2v8w]], [[2w97|2w97]]</td></tr> | ||
[[Category: Nowicki, M | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eir OCA], [http://pdbe.org/5eir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eir RCSB], [http://www.ebi.ac.uk/pdbsum/5eir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eir ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Fischer, P M]] | |||
[[Category: Nowicki, M W]] | |||
[[Category: Walkinshaw, M D]] | |||
[[Category: Complex]] | |||
[[Category: Eif4e]] | |||
[[Category: Inhibitor]] | |||
[[Category: Translation]] | |||
Revision as of 21:04, 10 September 2016
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
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