5gj6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5gj6 is ~~ON HOLD~~ ~~until Jun 28 2018~~

==Functional and structural characterization of P[19] rotavirus VP8* interaction with histo-blood group antigens==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5gj6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GJ6 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gj6 OCA], [http://pdbe.org/5gj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gj6 RCSB], [http://www.ebi.ac.uk/pdbsum/5gj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gj6 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/Q9Q2P6_9REOV Q9Q2P6_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]

__TOC__

</StructureSection>

[[Category: Duan, Z]]

[[Category: Sun, X]]

[[Category: Rotavirus]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5gj6 is ON HOLD  until Jun 28 2018
+==Functional and structural characterization of P[19] rotavirus VP8* interaction with histo-blood group antigens==
+<StructureSection load='5gj6' size='340' side='right' caption='[[5gj6]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5gj6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GJ6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gj6 OCA], [http://pdbe.org/5gj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gj6 RCSB], [http://www.ebi.ac.uk/pdbsum/5gj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gj6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q9Q2P6_9REOV Q9Q2P6_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]
+__TOC__
+</StructureSection>
+[[Category: Duan, Z]]
+[[Category: Sun, X]]
+[[Category: Rotavirus]]
+[[Category: Viral protein]]