5i0i: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5i0i is ~~ON HOLD until Paper Publication~~

==Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state==

~~Authors~~: ~~Isabet~~, T., ~~Sweeney~~, H.L., ~~Houdusse~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5i0i]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0I OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0I FirstGlance].

~~Description~~: ~~Crystal structure of myosin X~~ motor ~~domain~~ with ~~2IQ motifs~~ in ~~pre~~-~~powerstroke state~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5hmo|5hmo]], [[5hmp|5hmp]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0i OCA], [http://pdbe.org/5i0i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0i RCSB], [http://www.ebi.ac.uk/pdbsum/5i0i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0i ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Houdusse, A]]

[[Category: Isabet, T]]

[[Category: ~~Houdusse~~, A]]

[[Category: Sweeney, H L]]

[[Category: ~~Sweeney, H.L~~]]

[[Category: Molecular motor]]

[[Category: Motility]]

[[Category: Motor domain]]

[[Category: Motor protein]]

[[Category: Myosin]]

[[Category: Pre-powerstrocke state]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5i0i is ON HOLD  until Paper Publication
+==Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state==
+<StructureSection load='5i0i' size='340' side='right' caption='[[5i0i]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-Authors: Isabet, T., Sweeney, H.L., Houdusse, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5i0i]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0I FirstGlance]. <br>
-Description: Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hmo|5hmo]], [[5hmp|5hmp]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0i OCA], [http://pdbe.org/5i0i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0i RCSB], [http://www.ebi.ac.uk/pdbsum/5i0i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0i ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Houdusse, A]]
 [[Category: Isabet, T]]
-[[Category: Houdusse, A]]
+[[Category: Sweeney, H L]]
-[[Category: Sweeney, H.L]]
+[[Category: Molecular motor]]
+[[Category: Motility]]
+[[Category: Motor domain]]
+[[Category: Motor protein]]
+[[Category: Myosin]]
+[[Category: Pre-powerstrocke state]]