5l23: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5l23 is ~~ON HOLD~~

==Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand==

~~Authors~~: ~~Bhatt~~, V.S., ~~Krieger~~, I., ~~Sacchettini~~, J., ~~Cho, J~~.-H.

== Structural highlights ==

<table><tr><td colspan='2'>[[5l23]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L23 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L23 FirstGlance].

~~Description~~: ~~Crystal structure of the complex between the N~~-~~terminal SH3 domain~~ of ~~CrkII~~ and ~~a proline~~-~~rich ligand~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

[[Category: ~~Bhatt~~, ~~V.S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l23 OCA], [http://pdbe.org/5l23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l23 RCSB], [http://www.ebi.ac.uk/pdbsum/5l23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l23 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

__TOC__

</StructureSection>

[[Category: Bhatt, V S]]

[[Category: Cho, J H]]

[[Category: Krieger, I]]

[[Category: Sacchettini, J]]

[[Category: ~~Cho, J.-H~~]]

[[Category: Acetylation]]

[[Category: ~~Krieger, I~~]]

[[Category: Amidation]]

[[Category: C3g]]

[[Category: Crkii]]

[[Category: Protein binding]]

[[Category: Sh3]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5l23 is ON HOLD
+==Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand==
+<StructureSection load='5l23' size='340' side='right' caption='[[5l23]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-Authors: Bhatt, V.S., Krieger, I., Sacchettini, J., Cho, J.-H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5l23]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L23 FirstGlance]. <br>
-Description: Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-[[Category: Bhatt, V.S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l23 OCA], [http://pdbe.org/5l23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l23 RCSB], [http://www.ebi.ac.uk/pdbsum/5l23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l23 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
+__TOC__
+</StructureSection>
+[[Category: Bhatt, V S]]
+[[Category: Cho, J H]]
+[[Category: Krieger, I]]
 [[Category: Sacchettini, J]]
-[[Category: Cho, J.-H]]
+[[Category: Acetylation]]
-[[Category: Krieger, I]]
+[[Category: Amidation]]
+[[Category: C3g]]
+[[Category: Crkii]]
+[[Category: Protein binding]]
+[[Category: Sh3]]