Thiolase: Difference between revisions
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{{STRUCTURE_2iik| PDB=2iik | SIZE=400| SCENE=Thiolase/Thiolase/2 |right|CAPTION=Human 3-ketoacyl-CoA thiolase dimer, [[2iik]] }} | {{STRUCTURE_2iik| PDB=2iik | SIZE=400| SCENE=Thiolase/Thiolase/2 |right|CAPTION=Human 3-ketoacyl-CoA thiolase dimer, [[2iik]] }} | ||
== Function == | |||
Two different classes of '''thiolases''' are found.<br /> | Two different classes of '''thiolases''' are found.<br /> | ||
*'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid β oxidation<ref>PMID:16630629</ref> | *'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid β oxidation<ref>PMID:16630629</ref>.<br /> | ||
*'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref> | *'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref>. | ||
For Bacterial thiolase see [[Bacterial thiolase]] | For Bacterial thiolase see [[Bacterial thiolase]] | ||
== Structural highlights == | |||
The active site of 3-ketoacyl-CoA thiolase contains CoA<ref>PMID:25478839</ref>. | |||
== 3D Structures of Thiolase == | == 3D Structures of Thiolase == | ||
