5dhr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5dhr is ~~ON HOLD~~

==Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor==

~~Authors~~: ~~Gelin~~, M., ~~Paoletti~~, J., ~~Assairi~~, L., ~~Huteau~~, V., ~~Pochet~~, S.~~, Labesse, G~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5dhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DHR OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DHR FirstGlance].

~~Description~~: ~~Crystal structure~~ of NAD ~~kinase 1 from Listeria monocytogenes~~ in ~~complex with a novel inhibitor~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5AJ:5-AZIDO-8-[(2-{[2-(1H-BENZIMIDAZOL-2-YL)ETHYL]AMINO}-2-OXOETHYL)SULFANYL]-5-DEOXYADENOSINE'>5AJ</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dhr OCA], [http://pdbe.org/5dhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dhr RCSB], [http://www.ebi.ac.uk/pdbsum/5dhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dhr ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO]] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Assairi, L]]

[[Category: Gelin, M]]

[[Category: Huteau, V]]

[[Category: Labesse, G]]

[[Category: ~~Assairi~~, L]]

[[Category: Paoletti, J]]

[[Category: Pochet, S]]

[[Category: ~~Paoletti, J~~]]

[[Category: Tetrameric nad kinase]]

[[Category: ~~Gelin, M~~]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5dhr is ON HOLD
+==Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor==
+<StructureSection load='5dhr' size='340' side='right' caption='[[5dhr]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
-Authors: Gelin, M., Paoletti, J., Assairi, L., Huteau, V., Pochet, S., Labesse, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5dhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DHR FirstGlance]. <br>
-Description: Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5AJ:5-AZIDO-8-[(2-{[2-(1H-BENZIMIDAZOL-2-YL)ETHYL]AMINO}-2-OXOETHYL)SULFANYL]-5-DEOXYADENOSINE'>5AJ</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dhu|5dhu]], [[5dht|5dht]], [[5dhs|5dhs]], [[5dhq|5dhq]], [[5dhp|5dhp]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dhr OCA], [http://pdbe.org/5dhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dhr RCSB], [http://www.ebi.ac.uk/pdbsum/5dhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dhr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO]] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Assairi, L]]
+[[Category: Gelin, M]]
 [[Category: Huteau, V]]
 [[Category: Labesse, G]]
-[[Category: Assairi, L]]
+[[Category: Paoletti, J]]
 [[Category: Pochet, S]]
-[[Category: Paoletti, J]]
+[[Category: Tetrameric nad kinase]]
-[[Category: Gelin, M]]
+[[Category: Transferase]]