|
|
| Line 32: |
Line 32: |
| **[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal<br /> | | **[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal<br /> |
| **[[3m0a]] – hTRAF2 residues 266-329 + cIAP2<br /> | | **[[3m0a]] – hTRAF2 residues 266-329 + cIAP2<br /> |
| | |
| | *TRAF3 |
| | |
| | **[[4ghu]] – TRAF3 TRAF domain residues 376-567 + antiviral-signaling protein peptide - mouse <br /> |
| | |
| | *TRAF4 |
| | |
| | **[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain residues 281-470 <br /> |
| | |
| | *TRAF5 |
| | |
| | **[[4gjh]] – hTRAF5 TRAF domain residues 381-558 <br /> |
|
| |
|
| *TRAF6 | | *TRAF6 |
| Line 44: |
Line 56: |
| **[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide<br /> | | **[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide<br /> |
| **[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br /> | | **[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br /> |
| | **[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br /> |
| }} | | }} |
| == References == | | == References == |
| <references/> | | <references/> |
Revision as of 08:13, 15 September 2016
| Function
TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins[1]. TRAF2-6 have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK.
Structural highlights
The interaction of TRAF2 with the adaptor protein TRADD is bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions[2].
- ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:https://dx.doi.org/10.1038/sj.onc.1204788
- ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748
|
3D Structures of TNF receptor-associated factor
Updated on 15-September-2016
{"openlevels":0}
- TRAF1
- 3m0d – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 - human
- TRAF2
- 1ca4 – hTRAF2 TRAF domain residues 334-501
- 3knv – hTRAF2 RING+zinc finger 1 domains residues 1-133
- 3m06 – hTRAF2 residues 266-329
- TRAF2 complex with peptide
- 1ca9 – hTRAF2 TRAF domain + TNF-R2 peptide
- 1qsc, 1d00, 1czz – hTRAF2 TRAF domain + CD40 receptor peptide
- 1d01 – hTRAF2 TRAF domain + CD30 peptide
- 1czy – hTRAF2 TRAF domain + latent membrane protein peptide
- 1d0a – hTRAF2 TRAF domain + OX40L receptor peptide
- 1d0j – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide
- 1f3v – hTRAF2 TRAF domain + TRADD N terminal
- 3m0a – hTRAF2 residues 266-329 + cIAP2
- TRAF3
- 4ghu – TRAF3 TRAF domain residues 376-567 + antiviral-signaling protein peptide - mouse
- TRAF4
- TRAF5
- 4gjh – hTRAF5 TRAF domain residues 381-558
- TRAF6
- 1lb4 – hTRAF6 TRAF domain
- 2jmd, 2eci – hTRAF6 RING domain - NMR
- 3hcs – hTRAF6 RING+zinc finger 1-3 domains
- TRAF6 complex with peptide
- 1lb5 – hTRAF6 TRAF domain + RANK peptide
- 1lb6 – hTRAF6 TRAF domain + CD40 antigen peptide
- 3hct, 3hcu – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2
- 4z8m – hTRAF6 TRAF domain + antiviral-signaling protein peptide
References
