Transferrin: Difference between revisions
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<StructureSection load='3qyt' size='350' side='right' caption='Human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene=''> | |||
== Function == | == Function == | ||
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref> | '''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]]. | ||
== Relevance == | == Relevance == | ||
Carbohydrate-deficient TF may help diagnose alcoholic liver disease<ref>PMID:15908327</ref>. | Carbohydrate-deficient TF may help diagnose alcoholic liver disease<ref>PMID:15908327</ref>. | ||
== Structural highlights == | |||
TF contains two lobes: at the N and C termini. The Fe+3 ion is coordinated to several side chains, carbonate and sulfate ions<ref>PMID:23256035</ref>. | |||
</StructureSection> | |||
== 3D Structures of Transferrin == | == 3D Structures of Transferrin == | ||
