Transketolase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
'''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle. | <StructureSection load='2r8o' size='350' side='right' caption='E. coli transketolase 1 dimer complex with xylulose-5-phosphate-thiamine diphosphate adduct, ethylene glycol and Ca+2 ion (green) (PDB code [[2r8o]]).' scene=''> | ||
== Function == | |||
'''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle<ref>PMID:8369276</ref>. | |||
== Structural highlights == | |||
The active site of TKT contains a ligand-cofactor adduct. <ref>PMID:17914867</ref> | |||
</StructureSection> | |||
== 3D Structures of transketolase == | == 3D Structures of transketolase == | ||
| Line 53: | Line 59: | ||
**[[2r5n]] – EcTKT + TPP + ribose 5-P<br /> | **[[2r5n]] – EcTKT + TPP + ribose 5-P<br /> | ||
**[[3upt]] - BtTKT + TPP + ribose 5-P<br /> | **[[3upt]] - BtTKT + TPP + ribose 5-P<br /> | ||
**[[2r8o]] - EcTKT + TPP + xylulose 5-P | **[[2r8o]] - EcTKT 1 + TPP + xylulose 5-P | ||
**[[2r8p]] - EcTKT + TPP + fructose 6-P<br /> | **[[2r8p]] - EcTKT + TPP + fructose 6-P<br /> | ||
| Line 60: | Line 66: | ||
**[[4kxx]] - hTKT + TPP + seduheptulose 7-P<br /> | **[[4kxx]] - hTKT + TPP + seduheptulose 7-P<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
