TRAIL: Difference between revisions
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<StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]] scene=''> | |||
== Function == | == Function == | ||
'''TRAIL (TNF-related apoptosis-inducing ligand)''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. | '''TRAIL (TNF-related apoptosis-inducing ligand)''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. | ||
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== Disease == | == Disease == | ||
TRAIL concentrations are reduced in rheumatoid arithritis<ref>PMID:25962765</ref>. | TRAIL concentrations are reduced in rheumatoid arithritis<ref>PMID:25962765</ref>. | ||
</StructureSection> | |||
== 3D Structures of TRAIL == | == 3D Structures of TRAIL == | ||
