Tryptophan synthase

spinqualitylabelsall models Tryptophan synthaseα subunit (grey) and β subunit (green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) 1wbj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. Relevance TrpS is not found in animals hence it is tested as a possible drug target for tuberculosis, ocular and genital infections, cryptosporidiosis and as herbicide. Structural highlights The active site of TrpS subunit α contains the catalytic residues Glu and Asp which interact with G3P.

3D structures of tryptophan synthase

Updated on 27-September-2016

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• Tryptophan synthase α subunit
  • 3vnd - TrpS α subunit – Shewanella frigidimarina
    
  • 3tha - TrpS α subunit – Campylobacter jejuni
    
  • 3nav - TrpS α subunit – Vibrio cholerae
    
  • 1geq - PfTrpS α subunit - Pyrococcus furiosus
    
  • 2dzp, 2dzs, 2dzt, 2dzu, 2dzv, 2dzw, 2dzx, 2e09 - PfTrpS α subunit (mutant)
    
  • 1rd5 - TrpS α subunit – corn
    
  • 1ujp - TtTrpS α subunit
    
  • 1v7y, 1wq5, 1xc4 - EcTrpS α subunit
    
  • 1xcf - EcTrpS α subunit (mutant)
    
  • 2ekc - TrpS α subunit – Aquifex aeolicus
    
  • 5kmy, 5k9x - TrpS α subunit – Legionella pneumophila
    
• Tryptophan synthase α binary complex
  • 1wxj - TtTrpS α subunit + indole propanol phosphate
    
• Tryptophan synthase β subunit
  • 1x1q - TtTrpS β subunit – Thermus thermophilus
    
  • 2dh6 - EcTrpS β subunit]] - Escherichia coli
    
  • 2o2e, 2o2j - TrpS β subunit – Mycobacterium tuberculosis
    
  • 1v8z - PfTrpS β subunit
    
  • 4neg - TrpS β subunit – Bacillus anthracis
    
  • 4qys - TrpS β subunit – Sulfolobus solfataricus
    
• Tryptophan synthase β binary complex
  • 2dh5 - EcTrpS β subunit + PLP
    
• Tryptophan synthase α+β subunits
  • 1wdw - PfTrpS α + β subunits
    
• Tryptophan synthase α+β binary complex

• • 1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
    
  • 1a5a, 1k8x - StTrpS α (mutant) + β + PLP
    
  • 1k7x, 2j9z - StTrpS α + β (mutant) + PLP
    
  • 2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
    
  • 1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
    
  • 1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
    
  • 2j9y - StTrpS α + β (mutant) + enoic acid derivative
    
  • 3pr2, 4hn4, 4hpj, 4hpx, 4ht3, 4kkx - StTrpS α + β + inhibitor
    
  • 5kzm - TrpS α + β + PLP derivative – Francisella tularensis
    
  • 5kin - TrpS α + β + PLP derivative – Streptococcus pneumoniae
    
  • 5e0k - PfTrpS α + β + PLP derivative
    
• Tryptophan synthase α+β ternary complex with PLP and inhibitor
  • 1a50, 1cw2, 1c9d, 1cx9, 1c8v, 1c29, 2cle, 2clh, 2cli, 2clk, 2cll, 2clm, 2clo, 2clf, 5bw6, 4zqc, 4y6g, 4xug, 4wx2 - StTrpS α + β + inhibitor + PLP
    
  • 5cgq - StTrpS α + β + inhibitor + PLP + Trp
    
  • 1fuy - StTrpS α + β (mutant) + inhibitor + PLP
    
• Tryptophan synthase α+β ternary complex with PLP and IGP derivatives
  • 1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
    
  • 1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
    
  • 1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
    
  • 1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
    
  • 1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
    
  • 1qop - StTrpS α + β + IGP analog + PLP
    
  • 2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
• Tryptophan synthase α+β ternary complex with PLP and G3P derivatives
  • 1wbj - StTrpS α + β + G3P + PLP
    
  • 2j9x - StTrpS α + β + G3P + acrylic acid derivative
    
  • 1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
    
  • 1tjp - StTrpS α + β + G3P derivative + PLP
    
  • 2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
  • 1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP
    
• Tryptophan synthase α+β quaternary complex
  • 1a5s - StTrpS α + β + serine + inhibitor + PLP
    
  • 3cep - StTrpS α + β + G3P + indoline + PLP
    

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