5duj: Difference between revisions
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==Crystal structure of ldtMt2 in complex with Faropenem adduct== | |||
<StructureSection load='5duj' size='340' side='right' caption='[[5duj]], [[Resolution|resolution]] 2.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5duj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DUJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=DGF:(2R,5R)-2-[(2S,3R)-3-HYDROXY-1-OXOBUTAN-2-YL]-5-[(2R)-TETRAHYDROFURAN-2-YL]-2,5-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>DGF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5du7|5du7]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5duj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5duj OCA], [http://pdbe.org/5duj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5duj RCSB], [http://www.ebi.ac.uk/pdbsum/5duj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5duj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kumar, P]] | [[Category: Kumar, P]] | ||
[[Category: Lamichhane, G]] | [[Category: Lamichhane, G]] | ||
[[Category: Cell wall enzyme]] | |||
[[Category: Ld-transpeptidase]] | |||
[[Category: Peptidoglycan synthesis enzyme]] | |||
[[Category: Transferase]] | |||
Revision as of 17:05, 3 October 2016
Crystal structure of ldtMt2 in complex with Faropenem adduct
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