5j3r: Difference between revisions
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==Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster== | |||
<StructureSection load='5j3r' size='340' side='right' caption='[[5j3r]], [[Resolution|resolution]] 2.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5j3r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J3R FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3r OCA], [http://pdbe.org/5j3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j3r RCSB], [http://www.ebi.ac.uk/pdbsum/5j3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3r ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Glutaredoxins (Grxs) constitute a superfamily of proteins that perform diverse biological functions. The Saccharomyces cerevisiae glutaredoxin Grx6 not only serves as a glutathione (GSH)-dependent oxidoreductase and as a GSH transferase, but also as an essential [2Fe-2S]-binding protein. Here, the dimeric structure of the C-terminal domain of Grx6 (holo Grx6C), bridged by one [2Fe-2S] cluster coordinated by the active-site Cys136 and two external GSH molecules, is reported. Structural comparison combined with multiple-sequence alignment demonstrated that holo Grx6C is similar to the [2Fe-2S] cluster-incorporated dithiol Grxs, which share a highly conserved [2Fe-2S] cluster-binding pattern and dimeric conformation that is distinct from the previously identified [2Fe-2S] cluster-ligated monothiol Grxs. | |||
Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster.,Abdalla M, Dai YN, Chi CB, Cheng W, Cao DD, Zhou K, Ali W, Chen Y, Zhou CZ Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):732-737. Epub 2016, Sep 22. PMID:27710937<ref>PMID:27710937</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5j3r" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Abdalla, M]] | |||
[[Category: Ali, W]] | |||
[[Category: Cao, D D]] | |||
[[Category: Chen, Y]] | |||
[[Category: Cheng, W]] | |||
[[Category: Chi, C B]] | |||
[[Category: Dai, Y N]] | |||
[[Category: Zhou, C Z]] | |||
[[Category: Zhou, K]] | |||
[[Category: Glutaredoxin]] | |||
[[Category: Iron-sulfur cluster]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
Revision as of 17:32, 19 October 2016
Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster
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