5ea9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ea9 ~~is ON HOLD until Paper Publication~~

==Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130==

~~Authors~~: ~~Rocha, J~~.R.~~, Inaoka, D~~.K.~~, Cheleski, J~~., ~~Shiba~~, T., ~~Harada~~, S., ~~Montanari~~, ~~C.A.~~, ~~Kita~~, K.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ea9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EA9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EA9 FirstGlance].

~~Description~~: ~~Crystal Structure of Trypanosoma cruzi~~ Dihydroorotate ~~Dehydrogenase in Complex~~ with ~~Neq0130~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5LM:5-[(E)-3-THIOPHEN-2-YLPROP-2-ENYLIDENE]-1,3-DIAZINANE-2,4,6-TRIONE'>5LM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5e93|5e93]]</td></tr>

[[~~Category~~: ~~Shiba, T~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </td></tr>

[[Category: ~~Inaoka~~, ~~D.K~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ea9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ea9 OCA], [http://pdbe.org/5ea9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ea9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ea9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ea9 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

__TOC__

</StructureSection>

[[Category: Cheleski, J]]

[[Category: Harada, S]]

[[Category: ~~Cheleski~~, J]]

[[Category: Inaoka, D K]]

[[Category: Kita, K]]

[[Category: Montanari, C.A]]

[[Category: Montanari, C A]]

[[Category: Rocha, J.R]]

[[Category: Rocha, J R]]

[[Category: Shiba, T]]

[[Category: Covalent inhibitor]]

[[Category: Dihydroorotate dehydrogenase]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

[[Category: T. cruzi]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ea9 is ON HOLD  until Paper Publication
+==Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130==
+<StructureSection load='5ea9' size='340' side='right' caption='[[5ea9]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
-Authors: Rocha, J.R., Inaoka, D.K., Cheleski, J., Shiba, T., Harada, S., Montanari, C.A., Kita, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ea9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EA9 FirstGlance]. <br>
-Description: Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LM:5-[(E)-3-THIOPHEN-2-YLPROP-2-ENYLIDENE]-1,3-DIAZINANE-2,4,6-TRIONE'>5LM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e93|5e93]]</td></tr>
-[[Category: Shiba, T]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-[[Category: Inaoka, D.K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ea9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ea9 OCA], [http://pdbe.org/5ea9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ea9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ea9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ea9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
+__TOC__
+</StructureSection>
+[[Category: Cheleski, J]]
 [[Category: Harada, S]]
-[[Category: Cheleski, J]]
+[[Category: Inaoka, D K]]
 [[Category: Kita, K]]
-[[Category: Montanari, C.A]]
+[[Category: Montanari, C A]]
-[[Category: Rocha, J.R]]
+[[Category: Rocha, J R]]
+[[Category: Shiba, T]]
+[[Category: Covalent inhibitor]]
+[[Category: Dihydroorotate dehydrogenase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+[[Category: T. cruzi]]