5ecy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ecy is ~~ON HOLD~~

==Structure of the Shigella flexneri VapC mutant D98N crystal form 2==

~~Authors~~: Xu, K., ~~Dedic~~, E., ~~Brodersen~~, D.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ecy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECY FirstGlance]. <br>

~~Description~~: ~~Structure~~ of the ~~Shigella flexneri~~ VapC ~~mutant D98N crystal form 2~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ecd|5ecd]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecy OCA], [http://pdbe.org/5ecy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecy RCSB], [http://www.ebi.ac.uk/pdbsum/5ecy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecy ProSAT]</span></td></tr>

[[Category: ~~Brodersen~~, D.E]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/VAPC_SHIFL VAPC_SHIFL]] Toxic component of a toxin-antitoxin (TA) module. A tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet); these effects are neutralized by expression of cognate antitoxin VapB. The VapB/VapC complex probably regulates transcription of its own promoter.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref> Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Brodersen, D E]]

[[Category: Dedic, E]]

[[Category: Xu, K]]

[[Category: ~~Dedic, E~~]]

[[Category: Hydrolase]]

[[Category: Pin-domain]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ecy is ON HOLD
+==Structure of the Shigella flexneri VapC mutant D98N crystal form 2==
+<StructureSection load='5ecy' size='340' side='right' caption='[[5ecy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Xu, K., Dedic, E., Brodersen, D.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ecy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECY FirstGlance]. <br>
-Description: Structure of the Shigella flexneri VapC mutant D98N crystal form 2
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ecd|5ecd]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecy OCA], [http://pdbe.org/5ecy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecy RCSB], [http://www.ebi.ac.uk/pdbsum/5ecy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecy ProSAT]</span></td></tr>
-[[Category: Brodersen, D.E]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/VAPC_SHIFL VAPC_SHIFL]] Toxic component of a toxin-antitoxin (TA) module. A tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet); these effects are neutralized by expression of cognate antitoxin VapB. The VapB/VapC complex probably regulates transcription of its own promoter.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>   Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Brodersen, D E]]
+[[Category: Dedic, E]]
 [[Category: Xu, K]]
-[[Category: Dedic, E]]
+[[Category: Hydrolase]]
+[[Category: Pin-domain]]
+[[Category: Toxin]]