5emx: Difference between revisions

==Crystal structure of the S. cerevisiae Rtf1 histone modification domain mutant R124A R126A R128A==

<StructureSection load='5emx' size='340' side='right' caption='[[5emx]], [[Resolution|resolution]] 1.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[5emx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMX FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e8b|5e8b]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emx OCA], [http://pdbe.org/5emx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emx RCSB], [http://www.ebi.ac.uk/pdbsum/5emx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5emx ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RTF1_YEAST RTF1_YEAST]] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of SPT15, the TATA box-binding protein, and the relative activities of different TATA elements.<ref>PMID:15643076</ref> <ref>PMID:16246725</ref>