5jw1: Difference between revisions
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==Crystal structure of Celecoxib bound to S121P murine COX-2 mutant== | |||
<StructureSection load='5jw1' size='340' side='right' caption='[[5jw1]], [[Resolution|resolution]] 2.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jw1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CEL:4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE'>CEL</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jvy|5jvy]], [[5jvz|5jvz]]</td></tr> | ||
[[Category: Orlando, B | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw1 OCA], [http://pdbe.org/5jw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw1 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Prostaglandin-endoperoxide synthase]] | |||
[[Category: Malkowski, M G]] | |||
[[Category: Orlando, B J]] | |||
[[Category: Celebrex]] | |||
[[Category: Celecoxib]] | |||
[[Category: Cox-2]] | |||
[[Category: Coxib]] | |||
[[Category: Cyclooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 18:46, 26 October 2016
Crystal structure of Celecoxib bound to S121P murine COX-2 mutant
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