5ejm: Difference between revisions
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''' | {{Large structure}} | ||
==ThDP-Mn2+ complex of R413A variant of EcMenD soaked with 2-ketoglutarate for 35 min== | |||
<StructureSection load='5ejm' size='340' side='right' caption='[[5ejm]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ejm]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EJM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TD5:(4~{R})-4-[3-[(4-AZANYL-2-METHYL-PYRIMIDIN-5-YL)METHYL]-4-METHYL-5-[2-[OXIDANYL(PHOSPHONOOXY)PHOSPHORYL]OXYETHYL]-1,3-THIAZOL-3-IUM-2-YL]-4-OXIDANYL-BUTANOIC+ACID'>TD5</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ej4|5ej4]], [[5ej5|5ej5]], [[5ej6|5ej6]], [[5ej7|5ej7]], [[5ej8|5ej8]], [[5ej9|5ej9]], [[5eja|5eja]]</td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid_synthase 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.9 2.2.1.9] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ejm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejm OCA], [http://pdbe.org/5ejm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejm RCSB], [http://www.ebi.ac.uk/pdbsum/5ejm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejm ProSAT]</span></td></tr> | ||
</table> | |||
{{Large structure}} | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MEND_ECOLI MEND_ECOLI]] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).<ref>PMID:1459959</ref> <ref>PMID:17760421</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase]] | |||
[[Category: Chen, Y Z]] | |||
[[Category: Dong, C]] | [[Category: Dong, C]] | ||
[[Category: | [[Category: Guo, Z H]] | ||
[[Category: Song, H | [[Category: Song, H G]] | ||
[[Category: Sun, Y R]] | |||
[[Category: Post-decarboxylation intermediate of r413a variant of ecmend]] | |||
[[Category: Transferase]] | |||
Revision as of 18:26, 2 November 2016
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ThDP-Mn2+ complex of R413A variant of EcMenD soaked with 2-ketoglutarate for 35 min
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