5jy3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5jy3 is ON HOLD until Paper Publication~~

==CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927==

~~Authors: Muckelbauer, J.K.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5jy3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JY3 FirstGlance]. <br>

~~Description:~~ CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OX:2-[2-[2-[2,6-BIS(CHLORANYL)PHENYL]PROPAN-2-YL]-1-[2-FLUORANYL-4-[3-FLUORANYL-4-(HYDROXYMETHYL)-5-METHYLSULFONYL-PHENYL]PHENYL]IMIDAZOL-4-YL]PROPAN-2-OL'>6OX</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jy3 OCA], [http://pdbe.org/5jy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jy3 RCSB], [http://www.ebi.ac.uk/pdbsum/5jy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jy3 ProSAT]</span></td></tr>

[[Category: Muckelbauer, J.K]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

__TOC__

</StructureSection>

[[Category: Muckelbauer, J K]]

[[Category: Lxr-b]]

[[Category: Lxrb]]

[[Category: Ner]]

[[Category: Ner-i]]

[[Category: Nhr]]

[[Category: Nr1h2]]

[[Category: Rip15]]

[[Category: Transcription]]

[[Category: Unr]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5jy3 is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927==
+<StructureSection load='5jy3' size='340' side='right' caption='[[5jy3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Muckelbauer, J.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5jy3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JY3 FirstGlance]. <br>
-Description: CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OX:2-[2-[2-[2,6-BIS(CHLORANYL)PHENYL]PROPAN-2-YL]-1-[2-FLUORANYL-4-[3-FLUORANYL-4-(HYDROXYMETHYL)-5-METHYLSULFONYL-PHENYL]PHENYL]IMIDAZOL-4-YL]PROPAN-2-OL'>6OX</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jy3 OCA], [http://pdbe.org/5jy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jy3 RCSB], [http://www.ebi.ac.uk/pdbsum/5jy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jy3 ProSAT]</span></td></tr>
-[[Category: Muckelbauer, J.K]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Muckelbauer, J K]]
+[[Category: Lxr-b]]
+[[Category: Lxrb]]
+[[Category: Ner]]
+[[Category: Ner-i]]
+[[Category: Nhr]]
+[[Category: Nr1h2]]
+[[Category: Rip15]]
+[[Category: Transcription]]
+[[Category: Unr]]