Ribavirin: Difference between revisions
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1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide <ref name="gish">DOI: 10.1093/jac/dki405 </ref> | 1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide <ref name="gish">DOI: 10.1093/jac/dki405 </ref> | ||
<StructureSection load='' size='340' side='right' caption='Ribavirin PDB [[4PB1]]' scene='74/746008/Ribavirin_atalla2/1'> | <StructureSection load='' size='340' side='right' caption='Ribavirin PDB [[4PB1]]' scene='74/746008/Ribavirin_atalla2/1'> | ||
== Overview == | == Overview == | ||
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== Structure & Function == | == Structure & Function == | ||
While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alfa2b. Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis.The structure of Ribavirin resembles the structure of the nucleoside guanosine. Like guanosine, ribavirin is also water soluble and is able to mimic other purines as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that it’s heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. It’s structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. | While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alfa2b. Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis.The structure of Ribavirin resembles the structure of the nucleoside guanosine. Like guanosine, ribavirin is also water soluble and is able to mimic other purines as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that it’s heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. It’s structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. <scene name='74/746008/Ribavirin_atalla2/1'>Ribavirin</scene> | ||
== Disease == | == Disease == | ||
