Prinivil/Sandbox 1: Difference between revisions
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== Structure == | == Structure == | ||
[[Image: | [[Image:Prinivil_Bradykinin_binding_sites.png|thumb|right|Lisinopril/Bradykinin binding locations]]Lisinopril (prinivil) acts upon the membrane protein by forming tight and nonspecific contacts with the conserved residues in the <scene name='74/745974/Lisinopril_s2_interaction/1'>S2'</scene>, <scene name='74/745974/Lisinopril_s1_interaction/1'>S1'</scene>, and <scene name='74/745974/Lisinopril_s1_1_interaction/1'>S1</scene> positions of the <scene name='74/745974/Lisinopril_ace_complex/2'>ACE</scene>, which is viewed by using JSmol<ref>DOI 10.1002/ijch.201300024</ref> and Jmol.<ref>PMID:21638687</ref> The S1’ subsite contains Glu162 residue that interacts strongly with the lysine residue of lisinopril, the S1 subsite is surrounded with hydrophobic residues Phe512 and Val518, and the S2’ subsite contains Lys511 and Tyr520 to form strong hydrogen bonds with the C-terminus proline of lisinopril.<ref>DOI 10.1021/ci200083f</ref> | ||
To-do:<br/> | To-do:<br/> | ||
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- Include Green links for structure viewing of various ACE sites and relevant molecules<br/> | - Include Green links for structure viewing of various ACE sites and relevant molecules<br/> | ||
- Create structures for viewing | - Create structures for viewing | ||
