Ribavirin: Difference between revisions
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Ribavirin interacts with 3SFU by attaching the binding pocket, which is comprised of tyrosine at position 344 and aspartic acid at positions 250, 346, and 347. | Ribavirin interacts with 3SFU by attaching the binding pocket, which is comprised of tyrosine at position 344 and aspartic acid at positions 250, 346, and 347. | ||
=== Ribavirin with 4PB1=== | === Ribavirin with 4PB1=== | ||
Nucleoside transporters facilitate the transport of nucleosides across cell membranes to be used in protein synthesis. Concentrated NTs (CNTs) use the energy of ion gradients for active transportation , while equilibrative NTs (ENTs) transport nucleosides passively down their concentration gradient. Ribavirin is a substrate of ENT1, ENT2, and CNT2.CNT2 binds to the ribose of the ribavirin via hydrogen bonding involving glutamic acid at position 332, asparagine at position 368, and serine at position 371<ref>doi:10.7554/eLife.03604</ref>. | |||
== Disease == | == Disease == | ||
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#Kentsis, A, Topisirovic, I, Culjkovic, B, Shao, L, Borden, KLB. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the guanosine mRNA cap. Proc. Natl. Acad. Sci. 2004, 101:18105-18110. doi: 10.1073/pnas.0406927102 | #Kentsis, A, Topisirovic, I, Culjkovic, B, Shao, L, Borden, KLB. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the guanosine mRNA cap. Proc. Natl. Acad. Sci. 2004, 101:18105-18110. doi: 10.1073/pnas.0406927102 | ||
#Graci, JD, Cameron, CE. Mechanisms of action of ribavirin against distinct viruses. Rev. Med. Virol. 2006, 16: 37-48. doi: 10.1002/rmv.483 | #Graci, JD, Cameron, CE. Mechanisms of action of ribavirin against distinct viruses. Rev. Med. Virol. 2006, 16: 37-48. doi: 10.1002/rmv.483 | ||
#Johnson, ZL, Lee, JH, Lee, M, Kwon, DY, Hong, J, Lee, SY. Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. eLife. 2014, 3:e03604. doi: 10.7554/eLife.03604. | |||
