1q56: Difference between revisions
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|GENE= AGRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | |GENE= AGRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1pz7|1pz7]], [[1pz8|1pz8]], [[1pz9|1pz9]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q56 OCA], [http://www.ebi.ac.uk/pdbsum/1q56 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q56 RCSB]</span> | |||
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[[Category: nmj synapse]] | [[Category: nmj synapse]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:56 2008'' | ||
Revision as of 20:09, 30 March 2008
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| 1q56 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene: | AGRN (Gallus gallus) | ||||||||||||
| Related: | 1pz7, 1pz8, 1pz9
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state
Overview
The aggregation of acetylcholine receptors on postsynaptic membranes is a key step in neuromuscular junction development. This process depends on alternatively spliced forms of the proteoglycan agrin with "B-inserts" of 8, 11, or 19 residues in the protein's globular C-terminal domain, G3. Structures of the neural B8 and B11 forms of agrin-G3 were determined by X-ray crystallography. The structure of G3-B0, which lacks inserts, was determined by NMR. The agrin-G3 domain adopts a beta jellyroll fold. The B insert site is flanked by four loops on one edge of the beta sandwich. The loops form a surface that corresponds to a versatile interaction interface in the family of structurally related LNS proteins. NMR and X-ray data indicate that this interaction interface is flexible in agrin-G3 and that flexibility is reduced by Ca(2+) binding. The plasticity of the interaction interface could enable different splice forms of agrin to select between multiple binding partners.
About this Structure
1Q56 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:15016366
Page seeded by OCA on Sun Mar 30 23:08:56 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Gallus gallus
- Single protein
- Alexandrescu, A T.
- Frank, S.
- Jenny, M.
- Kammerer, R A.
- Landwehr, R.
- Maciejewski, M W.
- Rathgeb-Szabo, K.
- Ruegg, M A.
- Schulthess, T.
- Stetefeld, J.
- Achr aggregation
- Ca2+ regulation
- Conformational flexibility
- Laminin-g like domain
- Mrna splicing
- Musk activation
- Nmj synapse
