5l0m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5l0m is ~~ON HOLD until Paper Publication~~

==hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex==

~~Authors~~: ~~Tuntland~~, M.L., ~~Ortlund~~, E.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5l0m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L0M FirstGlance]. <br>

~~Description~~: ~~hLRH~~-~~1 DNA Binding Domain~~ -~~12bp Oct4 promoter complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l0m OCA], [http://pdbe.org/5l0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l0m RCSB], [http://www.ebi.ac.uk/pdbsum/5l0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l0m ProSAT]</span></td></tr>

[[Category: Tuntland, M.L]]

</table>

[[Category: ~~Ortlund, E.A~~]]

== Function ==

[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

__TOC__

</StructureSection>

[[Category: Ortlund, E A]]

[[Category: Tuntland, M L]]

[[Category: Dbd]]

[[Category: Lrh-1]]

[[Category: Nuclear receptor]]

[[Category: Oct4]]

[[Category: Transcription-dna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5l0m is ON HOLD  until Paper Publication
+==hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex==
+<StructureSection load='5l0m' size='340' side='right' caption='[[5l0m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Tuntland, M.L., Ortlund, E.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5l0m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L0M FirstGlance]. <br>
-Description: hLRH-1 DNA Binding Domain -12bp Oct4 promoter complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l0m OCA], [http://pdbe.org/5l0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l0m RCSB], [http://www.ebi.ac.uk/pdbsum/5l0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l0m ProSAT]</span></td></tr>
-[[Category: Tuntland, M.L]]
+</table>
-[[Category: Ortlund, E.A]]
+== Function ==
+[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
+__TOC__
+</StructureSection>
+[[Category: Ortlund, E A]]
+[[Category: Tuntland, M L]]
+[[Category: Dbd]]
+[[Category: Lrh-1]]
+[[Category: Nuclear receptor]]
+[[Category: Oct4]]
+[[Category: Transcription-dna complex]]