5elu: Difference between revisions

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'''Unreleased structure'''


The entry 5elu is ON HOLD  until Paper Publication
==Isoform-specific inhibition of SUMO-dependent protein-protein interactions==
 
<StructureSection load='5elu' size='340' side='right' caption='[[5elu]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
Authors: Hughes, D.J., Tiede, C., Hall, N., Tang, A.A.S., Trinh, C.H., Zajac, K., Mandal, U., Howell, G., Edwards, T.A., McPherson, M.J., Tomlinson, D.C., Whitehouse, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5elu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ELU FirstGlance]. <br>
Description: Isoform-specific inhibition of SUMO-dependent protein-protein interactions
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elu OCA], [http://pdbe.org/5elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5elu RCSB], [http://www.ebi.ac.uk/pdbsum/5elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5elu ProSAT]</span></td></tr>
[[Category: Whitehouse, A]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Edwards, T A]]
[[Category: Hall, N]]
[[Category: Hall, N]]
[[Category: Trinh, C.H]]
[[Category: Howell, G]]
[[Category: Tomlinson, D.C]]
[[Category: Hughes, D J]]
[[Category: Tang, A.A.S]]
[[Category: Mandal, U]]
[[Category: Edwards, T.A]]
[[Category: McPherson, M J]]
[[Category: Mcpherson, M.J]]
[[Category: Tang, A A.S]]
[[Category: Tiede, C]]
[[Category: Tiede, C]]
[[Category: Howell, G]]
[[Category: Tomlinson, D C]]
[[Category: Trinh, C H]]
[[Category: Whitehouse, A]]
[[Category: Zajac, K]]
[[Category: Zajac, K]]
[[Category: Hughes, D.J]]
[[Category: Signaling protein]]
[[Category: Mandal, U]]
[[Category: Sumoylation]]
[[Category: Ubiquitin]]
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