5fm5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5fm5 is ~~ON HOLD until Paper Publication~~

==Crystal structure of the myomesin:obscurin-like-1 complex==

~~Authors~~: ~~Pernigo~~, S., ~~Steiner~~, R.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5fm5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FM5 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~the myomesin~~:~~obscurin-like-1 complex~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fm4|5fm4]], [[5fm8|5fm8]]</td></tr>

[~~[Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm5 OCA], [http://pdbe.org/5fm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fm5 RCSB], [http://www.ebi.ac.uk/pdbsum/5fm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm5 ProSAT]</span></td></tr>

[[~~Category~~: ~~Steiner, R~~.A]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/OBSL1_HUMAN OBSL1_HUMAN]] Defects in OBSL1 are the cause of 3M syndrome type 2 (3M2) [MIM:[http://omim.org/entry/612921 612921]]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.<ref>PMID:19481195</ref>

== Function ==

[[http://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

== References ==

__TOC__

</StructureSection>

[[Category: Pernigo, S]]

[[Category: Steiner, R A]]

[[Category: Cytoskeletal protein]]

[[Category: Fibronectin domain]]

[[Category: Immunoglobulin-like domain]]

[[Category: M-band]]

[[Category: Protein complex]]

[[Category: Sarcomere]]

[[Category: Structural protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fm5 is ON HOLD  until Paper Publication
+==Crystal structure of the myomesin:obscurin-like-1 complex==
+<StructureSection load='5fm5' size='340' side='right' caption='[[5fm5]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors: Pernigo, S., Steiner, R.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fm5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FM5 FirstGlance]. <br>
-Description: Crystal structure of the myomesin:obscurin-like-1 complex
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fm4|5fm4]], [[5fm8|5fm8]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm5 OCA], [http://pdbe.org/5fm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fm5 RCSB], [http://www.ebi.ac.uk/pdbsum/5fm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm5 ProSAT]</span></td></tr>
-[[Category: Steiner, R.A]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/OBSL1_HUMAN OBSL1_HUMAN]] Defects in OBSL1 are the cause of 3M syndrome type 2 (3M2) [MIM:[http://omim.org/entry/612921 612921]]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.<ref>PMID:19481195</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Pernigo, S]]
+[[Category: Steiner, R A]]
+[[Category: Cytoskeletal protein]]
+[[Category: Fibronectin domain]]
+[[Category: Immunoglobulin-like domain]]
+[[Category: M-band]]
+[[Category: Protein complex]]
+[[Category: Sarcomere]]
+[[Category: Structural protein]]