5fnd: Difference between revisions
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==Dynamic Undocking and the Quasi-Bound State as tools for Drug Design== | |||
<StructureSection load='5fnd' size='340' side='right' caption='[[5fnd]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FND FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IQ5:N-(2-AZANYL-6-METHYL-1,3-BENZOTHIAZOL-5-YL)ETHANAMIDE'>IQ5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fnc|5fnc]], [[5fnf|5fnf]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnd OCA], [http://pdbe.org/5fnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnd RCSB], [http://www.ebi.ac.uk/pdbsum/5fnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Baker, L M]] | |||
[[Category: Barril, X]] | |||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
[[Category: Hubbard, R]] | |||
[[Category: Luque, F J]] | |||
[[Category: Matassova, N]] | |||
[[Category: Murray, J]] | [[Category: Murray, J]] | ||
[[Category: Roughley, S]] | |||
[[Category: Ruiz-Carmona, S]] | [[Category: Ruiz-Carmona, S]] | ||
[[Category: Schmidtke, P]] | [[Category: Schmidtke, P]] | ||
[[Category: | [[Category: Chaperone]] | ||
[[Category: | [[Category: Drug design]] | ||
[[Category: | [[Category: Hsp90]] | ||
[[Category: Oncology]] | |||
Revision as of 10:50, 10 December 2016
Dynamic Undocking and the Quasi-Bound State as tools for Drug Design
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