5dak: Difference between revisions
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==Crystal Structure of human Glutathione Transferase Pi complexed with a metalloid in the absence of Glutathione== | |||
<StructureSection load='5dak' size='340' side='right' caption='[[5dak]], [[Resolution|resolution]] 2.11Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dak]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DAK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dal|5dal]], [[5dcg|5dcg]], [[5ddl|5ddl]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dak OCA], [http://pdbe.org/5dak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dak RCSB], [http://www.ebi.ac.uk/pdbsum/5dak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dak ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Glutathione transferase]] | |||
[[Category: Morton, C J]] | |||
[[Category: Parker, L J]] | |||
[[Category: Parker, M W]] | |||
[[Category: Anti-cancer]] | |||
[[Category: Metalloid]] | |||
[[Category: Transferase]] | |||
Revision as of 02:06, 11 December 2016
Crystal Structure of human Glutathione Transferase Pi complexed with a metalloid in the absence of Glutathione
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