5f79: Difference between revisions
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==Influenza PB2 bound to an azaindole inhibitor== | |||
<StructureSection load='5f79' size='340' side='right' caption='[[5f79]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5f79]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F79 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4V7:N-[(1R,3S)-3-({5-FLUORO-2-[5-FLUORO-2-(HYDROXYMETHYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]PYRIMIDIN-4-YL}AMINO)CYCLOHEXYL]PYRROLIDINE-1-CARBOXAMIDE'>4V7</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f79 OCA], [http://pdbe.org/5f79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f79 RCSB], [http://www.ebi.ac.uk/pdbsum/5f79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f79 ProSAT]</span></td></tr> | ||
[[Category: Jacobs, M | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PB2_I75A0 PB2_I75A0]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Jacobs, M D]] | |||
[[Category: Polymerase]] | |||
[[Category: Small molecule inhibitor]] | |||
[[Category: Transcription-inhibitor complex]] | |||
Revision as of 02:10, 11 December 2016
Influenza PB2 bound to an azaindole inhibitor
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