5k6s: Difference between revisions
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The | ==The structure of the PP2A B56 subunit BubR1 complex== | ||
<StructureSection load='5k6s' size='340' side='right' caption='[[5k6s]], [[Resolution|resolution]] 2.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5k6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K6S FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6s OCA], [http://pdbe.org/5k6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k6s RCSB], [http://www.ebi.ac.uk/pdbsum/5k6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6s ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bajaj, R]] | |||
[[Category: Page, R]] | |||
[[Category: Peti, W]] | |||
[[Category: Wang, X]] | |||
[[Category: Cell cycle]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphatase]] | |||
[[Category: Regulator]] | |||
[[Category: Slim]] | |||
Revision as of 02:15, 11 December 2016
The structure of the PP2A B56 subunit BubR1 complex
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