WD repeat-containing protein: Difference between revisions

Revision as of 08:40, 14 December 2016

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Human WD-repeat protein 5 (grey) complex with histone H3 peptide (green) (PDB code 2h9m)

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Updated on 14-December-2016

2gnq, 2h68, 2h14, 2h9l – hWDR5 – human
3mxx, 3n0d, 3n0e – hWDR5 (mutant)
3smr, 3ur4, 4ia9, 4qqe, 4ql1 – hWDR5 + piperazine derivative
2cnx, 2co0, 2h6k, 2h6n, 2h6q, 2h13, 2h9m, 2h9n, 2h9p, 2g99, 2g9a, 2o9k, 3psl, 4a7j – hWDR5 + histone H3 peptide
3eg6, 3emh – hWDR5 + MLL1 peptide
4gm3, 4gm8, 4gm9, 4gmb – hWDR5 + peptide inhibitor
2xl2, 2xl3 – hWDR5 + retinoblastoma-binding protein 5 peptide
4o45 – hWDR5 + influenza NS1 C-terminal
4cy1 – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides
4cy2 – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide
4y7r – hWDR5 + Myc MbIIIb peptide
3uvk, 3uvl, 3uvm, 3uvn, 3uvo, 4erq, 4ery, 4es0, 4esg, 4ewr – hWDR5 + MLL peptide
4erz – hWDR5 + MLL4
3p4f – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide

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-<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey and pink) complex with histone H3 peptide (green and yellow) (PDB code [[2h9m]])'>
+<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey) complex with histone H3 peptide (green) (PDB code [[2h9m]])'>
-'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats.  WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD).  WDR5 contributes to histone modification.  It may position the N-terminal of histone H3 for efficient methylation at Lys4.  This methylation is implicated in the control of activation of cell lineage genes during embryogenesis.  WDR5 interacts with histone-lysine N-methyltransferase (MLL).  WDR5 forms a beta propeller structure.
 == Function ==
+'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats.  WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD).  WDR5 contributes to histone modification.  It may position the N-terminal of histone H3 for efficient methylation at Lys4.  This methylation is implicated in the control of activation of cell lineage genes during embryogenesis.  WDR5 interacts with histone-lysine N-methyltransferase (MLL)<ref>PMID:21531708</ref>.  WDR5 forms a beta propeller structure.
 == Disease ==
+Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.
 == Relevance ==